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Extensive SUMO Modification of Repressive Chromatin Factors Distinguishes Pluripotent from Somatic Cells
Post-translational modification by SUMO is a key regulator of cell identity. In mouse embryonic fibroblasts (MEFs), SUMO impedes reprogramming to pluripotency, while in embryonic stem cells (ESCs), it represses the emergence of totipotent-like cells, suggesting that SUMO targets distinct substrates...
Shranjeno v:
| izdano v: | Cell Rep |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cell Press
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7495044/ https://ncbi.nlm.nih.gov/pubmed/32937131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108146 |
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