Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy

Intratumor spatial heterogeneity facilitates therapeutic resistance in glioblastoma (GBM). Nonetheless, understanding of GBM heterogeneity is largely limited to the surgically resectable tumor core lesion while the seeds for recurrence reside in the unresectable tumor edge. In this study, stratifica...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bastola, Soniya, Pavlyukov, Marat S., Yamashita, Daisuke, Ghosh, Sadashib, Cho, Heejin, Kagaya, Noritaka, Zhang, Zhuo, Minata, Mutsuko, Lee, Yeri, Sadahiro, Hirokazu, Yamaguchi, Shinobu, Komarova, Svetlana, Yang, Eddy, Markert, James, Nabors, Louis B., Bhat, Krishna, Lee, James, Chen, Qin, Crossman, David K., Shin-Ya, Kazuo, Nam, Do-Hyun, Nakano, Ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494913/
https://ncbi.nlm.nih.gov/pubmed/32938908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18189-y
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