Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart

Intercalated discs (ICD), specific cell-to-cell contacts that connect adjacent cardiomyocytes, ensure mechanical and electrochemical coupling during contraction of the heart. Mutations in genes encoding ICD components are linked to cardiovascular diseases. Here, we show that loss of Xinβ, a newly-id...

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Vydáno v:Nat Commun
Hlavní autoři: Guo, Haipeng, Lu, Yao Wei, Lin, Zhiqiang, Huang, Zhan-Peng, Liu, Jianming, Wang, Yi, Seok, Hee Young, Hu, Xiaoyun, Ma, Qing, Li, Kathryn, Kyselovic, Jan, Wang, Qingchuan, Lin, Jenny L.-C., Lin, Jim J.-C., Cowan, Douglas B., Naya, Francisco, Chen, Yuguo, Pu, William T., Wang, Da-Zhi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494909/
https://ncbi.nlm.nih.gov/pubmed/32938943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18379-8
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