The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα–SOD2 pathway

Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. REGγ is emerging as 11S proteasome activator of 20S proteasome to promote the degradation of cellular proteins in a ubiquitin- and ATP-independent manner. Here, we found that REGγ was significantly upregul...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Xie, Yifan, Gao, Yang, Gao, Rifeng, Yang, Wenlong, Dong, Zheng, Moses, Robb E., Sun, Aijun, Li, Xiaotao, Ge, Junbo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494903/
https://ncbi.nlm.nih.gov/pubmed/32424140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0554-8
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