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The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα–SOD2 pathway
Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. REGγ is emerging as 11S proteasome activator of 20S proteasome to promote the degradation of cellular proteins in a ubiquitin- and ATP-independent manner. Here, we found that REGγ was significantly upregul...
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| Publicado no: | Cell Death Differ |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7494903/ https://ncbi.nlm.nih.gov/pubmed/32424140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0554-8 |
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