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The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα–SOD2 pathway
Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. REGγ is emerging as 11S proteasome activator of 20S proteasome to promote the degradation of cellular proteins in a ubiquitin- and ATP-independent manner. Here, we found that REGγ was significantly upregul...
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| Izdano u: | Cell Death Differ |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7494903/ https://ncbi.nlm.nih.gov/pubmed/32424140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0554-8 |
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