Загрузка...
Lysine 188 substitutions convert the pattern of proteasome activation by REGγ to that of REGs α and β
11S REGs (PA28s) are multimeric rings that bind proteasomes and stimulate peptide hydrolysis. Whereas REGα activates proteasomal hydrolysis of peptides with hydrophobic, acidic or basic residues in the P1 position, REGγ only activates cleavage after basic residues. We have isolated REGγ mutants capa...
Сохранить в:
| Главные авторы: | , , , , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2001
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125523/ https://ncbi.nlm.nih.gov/pubmed/11432824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.13.3359 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|