Lysine 188 substitutions convert the pattern of proteasome activation by REGγ to that of REGs α and β

11S REGs (PA28s) are multimeric rings that bind proteasomes and stimulate peptide hydrolysis. Whereas REGα activates proteasomal hydrolysis of peptides with hydrophobic, acidic or basic residues in the P1 position, REGγ only activates cleavage after basic residues. We have isolated REGγ mutants capa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Li, Jun, Gao, Xiaolin, Ortega, Joaquin, Nazif, Tamim, Joss, Lisa, Bogyo, Matthew, Steven, Alasdair C., Rechsteiner, Martin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2001
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC125523/
https://ncbi.nlm.nih.gov/pubmed/11432824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.13.3359
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