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Ubiquitin-independent degradation of cell cycle inhibitors by the REGγ proteasome
The cell cycle regulator p21(Cip1) is degraded by proteasomes independently of ubiquitination. We now show that degradation of p21 in vivo does not require the 19S proteasome lid, which contains the ubiquitin binding subunit. Instead, the major proteasomal pathway for p21 degradation involves an alt...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2031223/ https://ncbi.nlm.nih.gov/pubmed/17588519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.05.022 |
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