Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia

HIV-1 associated neurocognitive disorder (HAND) is characterized by neuroinflammation and glial activation that, together with the release of viral proteins, trigger a pathogenic cascade resulting in synaptodendritic damage and neurodegeneration that lead to cognitive impairment. However, the molecu...

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Udgivet i:Sci Rep
Main Authors: dos Reis, Roberta S., Sant, Shilpa, Keeney, Hannah, Wagner, Marc C. E., Ayyavoo, Velpandi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494890/
https://ncbi.nlm.nih.gov/pubmed/32938988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72214-0
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