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Improved haplotype inference by exploiting long-range linking and allelic imbalance in RNA-seq datasets
Haplotype reconstruction of distant genetic variants remains an unsolved problem due to the short-read length of common sequencing data. Here, we introduce HapTree-X, a probabilistic framework that utilizes latent long-range information to reconstruct unspecified haplotypes in diploid and polyploid...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7494856/ https://ncbi.nlm.nih.gov/pubmed/32938926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18320-z |
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