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Redefining the Clostridioides difficile σ(B) Regulon: σ(B) Activates Genes Involved in Detoxifying Radicals That Can Result from the Exposure to Antimicrobials and Hydrogen Peroxide

In many Gram-positive bacteria, the general stress response is regulated at the transcriptional level by the alternative sigma factor sigma B (σ(B)). In C. difficile, σ(B) has been implicated in protection against stressors such as reactive oxygen species (ROS) and antimicrobial compounds. Here, we...

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Detalhes bibliográficos
Publicado no:mSphere
Main Authors: Boekhoud, Ilse M., Michel, Annika-Marisa, Corver, Jeroen, Jahn, Dieter, Smits, Wiep Klaas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494833/
https://ncbi.nlm.nih.gov/pubmed/32938698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00728-20
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