Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells

New diagnoses of multiple myeloma (MM) tend to occur after the age of 60, by which time thymic output is severely reduced. As a consequence, lymphocyte recovery after lymphopenia-inducing anti-MM therapies relies on homeostatic proliferation of peripheral T cells rather than replenishment by new thy...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Cooke, Rachel Elizabeth, Quinn, Kylie Margaret, Quach, Hang, Harrison, Simon, Prince, Henry Miles, Koldej, Rachel, Ritchie, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494758/
https://ncbi.nlm.nih.gov/pubmed/33013907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.02153
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