Ghrelin uses the GHS-R1a/Gi/cAMP pathway and induces differentiation only in mature osteoblasts. This ghrelin pathway is impaired in AIS patients

We have examined the Acylated Ghrelin (AG)/Gi pathway in different human osteoblastic cell lines. We have found that: 1) AG induces differentiation/mineralization only in mature osteoblasts; 2) the expression of GHS-R1a increases up to the mature cell stage, 3) the action is mediated via the GHS-R/G...

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Enregistré dans:
Détails bibliographiques
Publié dans:Biochem Biophys Rep
Auteurs principaux: Barre, Ronan, Beton, Nicolas, Batut, Aurélie, Accabled, Frank, Sales de Gauzy, Jerome, Auriol, Françoise, Eddiry, Sanaa, Tauber, Maithe, Laurencin, Sara, Salles, Jean Pierre, Gennero, Isabelle
Format: Artigo
Langue:Inglês
Publié: Elsevier 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494670/
https://ncbi.nlm.nih.gov/pubmed/32984555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2020.100782
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