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Protein splicing activity of the Haloferax volcanii PolB-c intein is sensitive to homing endonuclease domain mutations

Inteins are selfish genetic elements residing in open reading frames that can splice post-translationally, resulting in the ligation of an uninterrupted, functional protein. Like other inteins, the DNA polymerase B (PolB) intein of the halophilic archaeon Haloferax volcanii has an active homing endo...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Robinzon, Shachar, Cawood, Alexandra R., Ruiz, Mercedes A., Gophna, Uri, Altman-Price, Neta, Mills, Kenneth V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494616/
https://ncbi.nlm.nih.gov/pubmed/32822531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00512
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