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CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials

Small molecule pharmacological inhibition of dominant human genetic disease is a feasible treatment that does not rely on the development of individual, patient-specific gene therapy vectors. However, the consequences of protein inhibition as a clinical therapeutic are not well-studied. In advance o...

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Detalhes bibliográficos
Publicado no:Hum Mutat
Main Authors: Wert, Katherine J., Koch, Susanne F., Velez, Gabriel, Hsu, Chun-Wei, Mahajan, MaryAnn, Bassuk, Alexander G., Tsang, Stephen H., Mahajan, Vinit B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493429/
https://ncbi.nlm.nih.gov/pubmed/31403230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.23894
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