Reverse transcriptase inhibition potentiates target therapy in BRAF-mutant melanomas: effects on cell proliferation, apoptosis, DNA-damage, ROS induction and mitochondrial membrane depolarization

ABSTRACT: Target therapies based on BRAF and MEK inhibitors (MAPKi) have changed the therapeutic landscape for metastatic melanoma patients bearing mutations in the BRAF kinase. However, the emergence of drug resistance imposes the necessity to conceive novel therapeutic strategies capable to achiev...

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Publicado en:Cell Commun Signal
Autores principales: Fattore, Luigi, Malpicci, Debora, Milite, Ciro, Castellano, Sabrina, Sbardella, Gianluca, Botti, Gerardo, Ascierto, Paolo A., Mancini, Rita, Ciliberto, Gennaro
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Short Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493390/
https://ncbi.nlm.nih.gov/pubmed/32933538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00633-7
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