Loss of SATB1 induces p21-dependent cellular senescence in post-mitotic dopaminergic neurons

SUMMARY: Cellular senescence is a mechanism used by mitotic cells to prevent uncontrolled cell division. As senescent cells persist in tissues, they cause local inflammation and are harmful to surrounding cells, contributing to aging. Generally, neurodegenerative diseases, such as Parkinson’s, are d...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Riessland, Markus, Kolisnyk, Benjamin, Kim, Tae Wan, Cheng, Jia, Ni, Jason, Pearson, Jordan A., Park, Emily J., Dam, Kevin, Acehan, Devrim, Ramos-Espiritu, Lavoisier S., Wang, Wei, Zhang, Jack, Shim, Jae-won, Ciceri, Gabriele, Brichta, Lars, Studer, Lorenz, Greengard, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493192/
https://ncbi.nlm.nih.gov/pubmed/31543366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.08.013
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