Loss of SATB1 induces p21-dependent cellular senescence in post-mitotic dopaminergic neurons

SUMMARY: Cellular senescence is a mechanism used by mitotic cells to prevent uncontrolled cell division. As senescent cells persist in tissues, they cause local inflammation and are harmful to surrounding cells, contributing to aging. Generally, neurodegenerative diseases, such as Parkinson’s, are d...

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Udgivet i:Cell Stem Cell
Main Authors: Riessland, Markus, Kolisnyk, Benjamin, Kim, Tae Wan, Cheng, Jia, Ni, Jason, Pearson, Jordan A., Park, Emily J., Dam, Kevin, Acehan, Devrim, Ramos-Espiritu, Lavoisier S., Wang, Wei, Zhang, Jack, Shim, Jae-won, Ciceri, Gabriele, Brichta, Lars, Studer, Lorenz, Greengard, Paul
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493192/
https://ncbi.nlm.nih.gov/pubmed/31543366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.08.013
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