A promising iPS-based single-cell cloning strategy revealing signatures of somatic mutations in heterogeneous normal cells

Single-cell genomics has advanced rapidly as trace-DNA amplification technologies evolved. However, current technologies are subject to a variety of pitfalls such as contamination, uneven genomic coverage, and amplification errors. Even for the “golden” strategy of single stem cell-derived clonal fo...

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Veröffentlicht in:Comput Struct Biotechnol J
Hauptverfasser: Miao, Xuexia, Li, Yueying, Zheng, Caihong, Wang, Lifei, Jin, Chen, Chen, Lei, Mi, Shuangli, Zhai, Weiwei, Wang, Qian-Fei, Cai, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Research Network of Computational and Structural Biotechnology 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493045/
https://ncbi.nlm.nih.gov/pubmed/32994891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.08.026
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