The Ubiquitin E3 Ligase Parkin Inhibits Innate Antiviral Immunity Through K48-Linked Polyubiquitination of RIG-I and MDA5

Innate immunity is the first-line defense against antiviral or antimicrobial infection. RIG-I and MDA5, which mediate the recognition of pathogen-derived nucleic acids, are essential for production of type I interferons (IFN). Here, we identified mitochondrion depolarization inducer carbonyl cyanide...

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Udgivet i:Front Immunol
Main Authors: Bu, Lang, Wang, Huan, Hou, Panpan, Guo, Shuting, He, Miao, Xiao, Jingshu, Li, Ping, Zhong, Yongheng, Jia, Penghui, Cao, Yuanyuan, Liang, Guanzhan, Yang, Chenwei, Chen, Lang, Guo, Deyin, Li, Chun-Mei
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7492610/
https://ncbi.nlm.nih.gov/pubmed/32983119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01926
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