Role of Ubiquitination in PTEN Cellular Homeostasis and Its Implications in GB Drug Resistance

Glioblastoma (GB) is the most common and aggressive brain malignancy, characterized by heterogeneity and drug resistance. PTEN, a crucial tumor suppressor, exhibits phosphatase-dependent (PI3K-AKT-mTOR pathway)/independent (nucleus stability) activities to maintain the homeostatic regulation of nume...

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Bibliografiska uppgifter
I publikationen:Front Oncol
Huvudupphovsmän: Xia, Qin, Ali, Sakhawat, Liu, Liqun, Li, Yang, Liu, Xuefeng, Zhang, Lingqiang, Dong, Lei
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2020
Ämnen:
Oncology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7492558/
https://ncbi.nlm.nih.gov/pubmed/32984016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01569
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