Age and life expectancy clocks based on machine learning analysis of mouse frailty

The identification of genes and interventions that slow or reverse aging is hampered by the lack of non-invasive metrics that can predict the life expectancy of pre-clinical models. Frailty Indices (FIs) in mice are composite measures of health that are cost-effective and non-invasive, but whether t...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Schultz, Michael B., Kane, Alice E., Mitchell, Sarah J., MacArthur, Michael R., Warner, Elisa, Vogel, David S., Mitchell, James R., Howlett, Susan E., Bonkowski, Michael S., Sinclair, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7492249/
https://ncbi.nlm.nih.gov/pubmed/32934233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18446-0
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