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Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton

Neutrophils rely on glycolysis for energy production. How mitochondria regulate neutrophil function is not fully understood. Here, we report that mitochondrial outer membrane protein Mitofusin 2 (MFN2) regulates neutrophil homeostasis and chemotaxis in vivo. Mfn2-deficient neutrophils are released f...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Zhou, Wenqing, Hsu, Alan Y., Wang, Yueyang, Syahirah, Ramizah, Wang, Tianqi, Jeffries, Jacob, Wang, Xu, Mohammad, Haroon, Seleem, Mohamed N., Umulis, David, Deng, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7491649/
https://ncbi.nlm.nih.gov/pubmed/32788232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.248880
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