Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia

ABSTRACT: Frontotemporal dementia (FTD) is amongst the most prevalent early onset dementias and even though it is clinically, pathologically and genetically heterogeneous, a crucial involvement of metabolic perturbations in FTD pathology is being recognized. However, changes in metabolism at the cel...

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Veröffentlicht in:Mol Brain
Hauptverfasser: Aldana, Blanca I., Zhang, Yu, Jensen, Pia, Chandrasekaran, Abinaya, Christensen, Sofie K., Nielsen, Troels T., Nielsen, Jørgen E., Hyttel, Poul, Larsen, Martin R., Waagepetersen, Helle S., Freude, Kristine K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7491073/
https://ncbi.nlm.nih.gov/pubmed/32928252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-020-00658-6
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