Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1

Skin fibroblasts were obtained from a 48-year-old presymptomatic woman carrying a A79V mutation in the presenilin 1 gene (PSEN1), causing Alzheimer's disease (AD). Induced pluripotent stem cell (iPSCs) were derived via transfection with episomal vectors carrying hOCT4, hSOX2, hKLF2, hL-MYC, hLI...

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Main Authors: Tong Li, Carlota Pires, Troels T. Nielsen, Gunhild Waldemar, Lena E. Hjermind, Jørgen E. Nielsen, Andras Dinnyes, Poul Hyttel, Kristine K. Freude
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016-03-01
Colecção:Stem Cell Research
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S187350611600012X
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