Effects of hyperinsulinemia on acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor via the PI3K/AKT pathway in non-small cell lung cancer cells in vitro

Patients with lung cancer harboring activating epidermal growth factor (EGFR) mutations and pre-existing diabetes have been demonstrated to exhibit poor responses to first-line EGFR-tyrosine kinase inhibitor (TKI) therapy. Strategies for the management of acquired resistance to EGFR-TKIs in patients...

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Publicado no:Oncol Lett
Main Authors: Chiu, Hsin-Yi, Chiang, Chi-Ming, Yeh, Szu-Peng, Jong, De-Shien, Wu, Leang-Shin, Liu, Hung-Chang, Chiu, Chih-Hsien
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7491043/
https://ncbi.nlm.nih.gov/pubmed/32963612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2020.12069
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