Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder

The current opioid epidemic necessitates a better understanding of human addiction neurobiology to develop efficacious treatment approaches. Here, we perform genome-wide assessment of chromatin accessibility of the human striatum in heroin users and matched controls. Our study reveals distinct neuro...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Egervari, Gabor, Akpoyibo, Diana, Rahman, Tanni, Fullard, John F., Callens, James E., Landry, Joseph A., Ly, Annie, Zhou, Xianxiao, Warren, Noël, Hauberg, Mads E., Hoffman, Gabriel, Ellis, Randy, Ferland, Jacqueline-Marie N., Miller, Michael L., Keller, Eva, Zhang, Bin, Roussos, Panos, Hurd, Yasmin L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7490718/
https://ncbi.nlm.nih.gov/pubmed/32929078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18114-3
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