Beneficial Effect of Chloroquine and Amodiaquine on Type 1 Diabetic Tubulopathy by Attenuating Mitochondrial Nox4 and Endoplasmic Reticulum Stress

BACKGROUND: Oxidative stress induced by chronic hyperglycemia is recognized as a significant mechanistic contributor to the development of diabetic kidney disease (DKD). Nonphagocytic nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) is a major source of reactive oxygen species (ROS) in m...

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Vydáno v:J Korean Med Sci
Hlavní autoři: Kang, Jun Mo, Lee, Hyun-Seob, Kim, Junghyun, Yang, Dong Ho, Jeong, Hye Yun, Lee, Yu Ho, Kim, Dong-Jin, Park, Seon Hwa, Sung, MinJi, Kim, Jaehee, An, Hyun-Ju, Lee, Sang Ho, Lee, So-Young
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Academy of Medical Sciences 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7490204/
https://ncbi.nlm.nih.gov/pubmed/32924342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2020.35.e305
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