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PARP Inhibitors in Metastatic Prostate Cancer: Evidence to Date
Poly (ADP-ribose) polymerase inhibitors (PARPi) are a unique class of antineoplastic agents that function by inducing synthetic lethality. Synthetic lethality occurs when PARPi and either another agent or an underlying genetic alteration together lead to overwhelming DNA damage and ultimately cell d...
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| Published in: | Cancer Manag Res |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Dove
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7489946/ https://ncbi.nlm.nih.gov/pubmed/32982407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S227033 |
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