Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways

The anticancer agent 5-fluorouracil (5-FU) is cytotoxic and often used to treat various cancers. 5-FU is thought to inhibit the enzyme thymidylate synthase, which plays a role in nucleotide synthesis and has been found to induce single- and double-strand DNA breaks. ATR Ser/Thr kinase (ATR) is a pri...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Ito, Soichiro S., Nakagawa, Yosuke, Matsubayashi, Masaya, Sakaguchi, Yoshihiko M., Kobashigawa, Shinko, Matsui, Takeshi K., Nanaura, Hitoki, Nakanishi, Mari, Kitayoshi, Fumika, Kikuchi, Sotaro, Kajihara, Atsuhisa, Tamaki, Shigehiro, Sugie, Kazuma, Kashino, Genro, Takahashi, Akihisa, Hasegawa, Masatoshi, Mori, Eiichiro, Kirita, Tadaaki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2020
Konular:
Cell Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7489910/
https://ncbi.nlm.nih.gov/pubmed/32675286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013726
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller