Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways

The anticancer agent 5-fluorouracil (5-FU) is cytotoxic and often used to treat various cancers. 5-FU is thought to inhibit the enzyme thymidylate synthase, which plays a role in nucleotide synthesis and has been found to induce single- and double-strand DNA breaks. ATR Ser/Thr kinase (ATR) is a pri...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ito, Soichiro S., Nakagawa, Yosuke, Matsubayashi, Masaya, Sakaguchi, Yoshihiko M., Kobashigawa, Shinko, Matsui, Takeshi K., Nanaura, Hitoki, Nakanishi, Mari, Kitayoshi, Fumika, Kikuchi, Sotaro, Kajihara, Atsuhisa, Tamaki, Shigehiro, Sugie, Kazuma, Kashino, Genro, Takahashi, Akihisa, Hasegawa, Masatoshi, Mori, Eiichiro, Kirita, Tadaaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7489910/
https://ncbi.nlm.nih.gov/pubmed/32675286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013726
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