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N(6)-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling

N(6)-Methyladenosine (m(6)A), the methylation of the adenosine base at the nitrogen 6 position, is the most common epitranscriptomic modification of mRNA that affects a wide variety of biological functions. We have previously reported that hepatitis B viral RNAs are m(6)A-modified, displaying a dual...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Kim, Geon-Woo, Imam, Hasan, Khan, Mohsin, Siddiqui, Aleem
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7489896/
https://ncbi.nlm.nih.gov/pubmed/32719095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014260
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