MicroRNA-34c Inhibits Osteogenic Differentiation and Valvular Interstitial Cell Calcification via STC1-Mediated JNK Pathway in Calcific Aortic Valve Disease

Calcific aortic valve disease (CAVD), a common heart valve disease, is increasingly prevalent worldwide and causes high morbidity and mortality. Here, we aimed to investigate a possible role for miR-34c in the development of osteogenic differentiation during CAVD and to find out the underlying mecha...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Yang, Lieming, Zhu, Xinyuan, Ni, Yingying, Wu, Dawei, Tian, Yikui, Chen, Zhi, Li, Mingbiao, Zhang, Hao, Liang, Degang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7489094/
https://ncbi.nlm.nih.gov/pubmed/32982764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00829
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