Thymoquinone and Difluoromethylornithine (DFMO) Synergistically Induce Apoptosis of Human Acute T Lymphoblastic Leukemia Jurkat Cells Through the Modulation of Epigenetic Pathways

Thymoquinone (TQ), a natural anticancer agent exerts cytotoxic effects on several tumors by targeting multiple pathways, including apoptosis. Difluoromethylornithine (DFMO), an irreversible inhibitor of the ornithine decarboxylase (ODC) enzyme, has shown promising inhibitory activities in many cance...

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Detalhes bibliográficos
Publicado no:Technol Cancer Res Treat
Main Authors: Alhosin, Mahmoud, Razvi, Syed Shoeb I., Sheikh, Ryan A., Khan, Jalaluddin A., Zamzami, Mazin A., Choudhry, Hani
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488875/
https://ncbi.nlm.nih.gov/pubmed/32912061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1533033820947489
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