SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil extracellular traps (NETs) have been described as important mediators of tissue damage in inflammatory diseases, we investigate...

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Published in:J Exp Med
Main Authors: Veras, Flavio Protasio, Pontelli, Marjorie Cornejo, Silva, Camila Meirelles, Toller-Kawahisa, Juliana E., de Lima, Mikhael, Nascimento, Daniele Carvalho, Schneider, Ayda Henriques, Caetité, Diego, Tavares, Lucas Alves, Paiva, Isadora M., Rosales, Roberta, Colón, David, Martins, Ronaldo, Castro, Italo Araujo, Almeida, Glaucia M., Lopes, Maria Isabel Fernandes, Benatti, Maíra Nilson, Bonjorno, Letícia Pastorelli, Giannini, Marcela Cavichioli, Luppino-Assad, Rodrigo, Almeida, Sérgio Luna, Vilar, Fernando, Santana, Rodrigo, Bollela, Valdes R., Auxiliadora-Martins, Maria, Borges, Marcos, Miranda, Carlos Henrique, Pazin-Filho, Antônio, da Silva, Luis Lamberti P., Cunha, Larissa, Zamboni, Dario S., Dal-Pizzol, Felipe, Leiria, Luiz O., Siyuan, Li, Batah, Sabrina, Fabro, Alexandre, Mauad, Thais, Dolhnikoff, Marisa, Duarte-Neto, Amaro, Saldiva, Paulo, Cunha, Thiago Mattar, Alves-Filho, José Carlos, Arruda, Eurico, Louzada-Junior, Paulo, Oliveira, Renê Donizeti, Cunha, Fernando Queiroz
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2020
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Brief Definitive Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488868/
https://ncbi.nlm.nih.gov/pubmed/32926098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201129
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