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A Phosphoramidate Strategy Enables Membrane Permeability of a Non-nucleotide Inhibitor of the Prolyl Isomerase Pin1
[Image: see text] The membrane permeability of nucleotide-based drugs, such as sofosbuvir (Sovaldi), requires installation of phosphate-caging groups. One strategy, termed “ProTide”, masks the anionic phosphate through an N-linked amino ester and an O-linked aromatic phospho-ester, such that release...
שמור ב:
| הוצא לאור ב: | ACS Med Chem Lett |
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| Main Authors: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Chemical
Society
2020
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7488286/ https://ncbi.nlm.nih.gov/pubmed/32944137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00170 |
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