A Rat Model of Cocaine-Alcohol Polysubstance Use Reveals Altered Cocaine Seeking and Glutamate Levels in the Nucleus Accumbens

Preclinical models of cocaine use disorder are widely utilized to identify neuroadaptations underlying cocaine seeking and to screen medications to reduce seeking. However, while the majority of cocaine users engage in poly-substance use (PSU), a minority of preclinical studies employ PSU models. We...

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Bibliographic Details
Published in:Front Neurosci
Main Authors: Stennett, Bethany A., Knackstedt, Lori A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488193/
https://ncbi.nlm.nih.gov/pubmed/32982672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00877
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