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Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy

BACKGROUND: Antifungals act on fungal sterols structurally similar to human cholesterol. Ketoconazole reversibly suppresses steroidogenesis by inhibiting cytochrome P450 enzymes and interferes with dihydrotestosterone (DHT) activity by binding to the androgen receptor. Hypospadias was reported in in...

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Bibliografiske detaljer
Udgivet i:Int J Pediatr Endocrinol
Main Authors: Gujral, Jasmine, Costin, Gertrude, Khurana, Divya, Yau, Mabel, Wallach, Elizabeth, Romero, Christopher J., Wilkes, Meredith, Sethuram, Swathi, Rapaport, Robert
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488073/
https://ncbi.nlm.nih.gov/pubmed/32944019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13633-020-00087-1
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