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Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy

BACKGROUND: Antifungals act on fungal sterols structurally similar to human cholesterol. Ketoconazole reversibly suppresses steroidogenesis by inhibiting cytochrome P450 enzymes and interferes with dihydrotestosterone (DHT) activity by binding to the androgen receptor. Hypospadias was reported in in...

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Detalhes bibliográficos
Publicado no:Int J Pediatr Endocrinol
Main Authors: Gujral, Jasmine, Costin, Gertrude, Khurana, Divya, Yau, Mabel, Wallach, Elizabeth, Romero, Christopher J., Wilkes, Meredith, Sethuram, Swathi, Rapaport, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488073/
https://ncbi.nlm.nih.gov/pubmed/32944019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13633-020-00087-1
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