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Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy
BACKGROUND: Antifungals act on fungal sterols structurally similar to human cholesterol. Ketoconazole reversibly suppresses steroidogenesis by inhibiting cytochrome P450 enzymes and interferes with dihydrotestosterone (DHT) activity by binding to the androgen receptor. Hypospadias was reported in in...
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| Publicado no: | Int J Pediatr Endocrinol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7488073/ https://ncbi.nlm.nih.gov/pubmed/32944019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13633-020-00087-1 |
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