Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy

BACKGROUND: Antifungals act on fungal sterols structurally similar to human cholesterol. Ketoconazole reversibly suppresses steroidogenesis by inhibiting cytochrome P450 enzymes and interferes with dihydrotestosterone (DHT) activity by binding to the androgen receptor. Hypospadias was reported in in...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Pediatr Endocrinol
Hauptverfasser: Gujral, Jasmine, Costin, Gertrude, Khurana, Divya, Yau, Mabel, Wallach, Elizabeth, Romero, Christopher J., Wilkes, Meredith, Sethuram, Swathi, Rapaport, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Case Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488073/
https://ncbi.nlm.nih.gov/pubmed/32944019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13633-020-00087-1
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