Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice

In tauopathies, phosphorylation, acetylation, cleavage and other modifications of tau drive intracellular generation of diverse forms of toxic tau aggregates and associated seeding activity, which have been implicated in subsequent synaptic failure and neurodegeneration. Suppression of this wide ran...

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Bibliographic Details
Published in:Acta Neuropathol Commun
Main Authors: Yang, Tao, Liu, Harry, Tran, Kevin C., Leng, Albert, Massa, Stephen M., Longo, Frank M.
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7487850/
https://ncbi.nlm.nih.gov/pubmed/32891185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01034-0
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