Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila

A large intronic hexanucleotide repeat expansion (GGGGCC) within the C9orf72 (C9orf72-SMCR8 Complex Subunit) locus is the most prevalent genetic cause of both Frontotemporal Dementia (FTD) and Motor Neuron Disease (MND). In patients this expansion is typically hundreds to thousands of repeat units i...

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Bibliografske podrobnosti
izdano v:Acta Neuropathol Commun
Main Authors: West, Ryan J. H., Sharpe, Joanne L., Voelzmann, André, Munro, Anna L., Hahn, Ines, Baines, Richard A., Pickering-Brown, Stuart
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7487709/
https://ncbi.nlm.nih.gov/pubmed/32894207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01028-y
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