Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo

BACKGROUND: Alpha-1 antitrypsin deficiency (AATD)-mediated liver disease is a toxic “gain-of-function” inflammation in the liver associated with intracellular retention of mutant alpha-1 antitrypsin. The clinical presentation of the disease includes fibrosis, cirrhosis and liver failure. However, th...

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Vydáno v:Cell Commun Signal
Hlavní autoři: Khodayari, Nazli, Oshins, Regina, Holliday, L. Shannon, Clark, Virginia, Xiao, Qiang, Marek, George, Mehrad, Borna, Brantly, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7487708/
https://ncbi.nlm.nih.gov/pubmed/32887613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00648-0
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