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Negative Allosteric Modulators of Cannabinoid Receptor 2: Protein Modeling, Binding Site Identification and Molecular Dynamics Simulations in the Presence of an Orthosteric Agonist

Selective activation of the cannabinoid receptor subtype 2 (CB2) shows promise for treating pain, inflammation, multiple sclerosis, cancer, ischemic/reperfusion injury, and osteoporosis. Target selectivity and off-target side effects are two major limiting factors for orthosteric ligands, and, there...

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Foilsithe in:J Biomol Struct Dyn
Main Authors: Pandey, Pankaj, Roy, Kuldeep K., Doerksen, Robert J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7487276/
https://ncbi.nlm.nih.gov/pubmed/30652534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07391102.2019.1567384
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