Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease

Late onset Alzheimer disease (LOAD) is traditionally considered as a separate disease from vascular dementia (VAD). However, growing evidence suggests that β-amyloid (Aβ) accumulation, that initiates LOAD-related neurodegeneration, is preceded by vascular events. Previous in vitro studies showed tha...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zuliani, Giovanni, Trentini, Alessandro, Rosta, Valentina, Guerrini, Remo, Pacifico, Salvatore, Bonazzi, Stefania, Guiotto, Anna, Passaro, Angelina, Seripa, Davide, Valacchi, Giuseppe, Cervellati, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486910/
https://ncbi.nlm.nih.gov/pubmed/32917964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72168-3
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