Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer’s disease

Beta-secretase (BACE1) is a key enzyme in the formation of amyloid-β; its activity/concentration is increased in brain and cerebrospinal fluid of patients with late-onset Alzheimer’s disease (LOAD). Since BACE1 was found also in blood, we evaluated its potential as peripheral biomarker. To this aim,...

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Publicat a:GeroScience
Autors principals: Cervellati, Carlo, Trentini, Alessandro, Rosta, Valentina, Passaro, Angelina, Bosi, Cristina, Sanz, Juana Maria, Bonazzi, Stefania, Pacifico, Salvatore, Seripa, Davide, Valacchi, Giuseppe, Guerini, Remo, Zuliani, Giovanni
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2019
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031490/
https://ncbi.nlm.nih.gov/pubmed/31745860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-019-00127-6
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