Febrile temperature change modulates CD4 T cell differentiation via a TRPV channel-regulated Notch-dependent pathway

Fever is a conserved and prominent response to infection. Yet, the issue of how CD4 T cell responses are modulated if they occur at fever temperatures remains poorly addressed. We have examined the priming of naive CD4 T cells in vitro at fever temperatures, and we report notable fever-mediated modu...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Umar, Danish, Das, Arundhoti, Gupta, Suman, Chattopadhyay, Somdeb, Sarkar, Debayan, Mirji, Gauri, Kalia, Jeet, Arimbasseri, Gopalakrishnan Aneeshkumar, Durdik, Jeannine Marie, Rath, Satyajit, George, Anna, Bal, Vineeta
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486768/
https://ncbi.nlm.nih.gov/pubmed/32839313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922683117
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