Direct Delivery of Apatite Nanoparticle-Encapsulated siRNA Targeting TIMP-1 for Intractable Abnormal Scars

Hypertrophic scars (HSs) and keloids are histologically characterized by excessive extracellular matrix (ECM) deposition. ECM deposition depends on the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteases (TIMPs). TIMP-1 has been linked to ECM degradation and is...

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Foilsithe in:Mol Ther Nucleic Acids
Main Authors: Aoki, Masayo, Matsumoto, Noriko M., Dohi, Teruyuki, Kuwahawa, Hiroaki, Akaishi, Satoshi, Okubo, Yuri, Ogawa, Rei, Yamamoto, Hirofumi, Takabe, Kazuaki
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Gene & Cell Therapy 2020
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486579/
https://ncbi.nlm.nih.gov/pubmed/32911344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.08.005
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