Direct Delivery of Apatite Nanoparticle-Encapsulated siRNA Targeting TIMP-1 for Intractable Abnormal Scars

Hypertrophic scars (HSs) and keloids are histologically characterized by excessive extracellular matrix (ECM) deposition. ECM deposition depends on the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteases (TIMPs). TIMP-1 has been linked to ECM degradation and is...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Aoki, Masayo, Matsumoto, Noriko M., Dohi, Teruyuki, Kuwahawa, Hiroaki, Akaishi, Satoshi, Okubo, Yuri, Ogawa, Rei, Yamamoto, Hirofumi, Takabe, Kazuaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486579/
https://ncbi.nlm.nih.gov/pubmed/32911344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.08.005
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