Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation

Endosome maturation depends on membrane contact sites (MCSs) formed between endoplasmic reticulum (ER) and endolysosomes (LyLEs). The mechanism underlying lipid supply for this process and its pathophysiological relevance remains unclear, however. Here, we identify PDZD8—the mammalian ortholog of a...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Shirane, Michiko, Wada, Mariko, Morita, Keiko, Hayashi, Nahoki, Kunimatsu, Reina, Matsumoto, Yuki, Matsuzaki, Fumiko, Nakatsumi, Hirokazu, Ohta, Keisuke, Tamura, Yasushi, Nakayama, Keiichi I.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486383/
https://ncbi.nlm.nih.gov/pubmed/32917905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18413-9
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