Elucidating the role of metal ions in carbonic anhydrase catalysis

Why metalloenzymes often show dramatic changes in their catalytic activity when subjected to chemically similar but non-native metal substitutions is a long-standing puzzle. Here, we report on the catalytic roles of metal ions in a model metalloenzyme system, human carbonic anhydrase II (CA II). Thr...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Kim, Jin Kyun, Lee, Cheol, Lim, Seon Woo, Adhikari, Aniruddha, Andring, Jacob T., McKenna, Robert, Ghim, Cheol-Min, Kim, Chae Un
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486293/
https://ncbi.nlm.nih.gov/pubmed/32917908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18425-5
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