The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Molecular glue compounds induce protein-protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation.(1) Unlike traditional enzyme inhibitors, such molecular glue degraders act sub-stoichiometrically to catalyse rapid depletion of previously inaccessible targets.(2) T...

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書誌詳細
出版年:Nature
主要な著者: Słabicki, Mikołaj, Kozicka, Zuzanna, Petzold, Georg, Li, Yen-Der, Manojkumar, Manisha, Bunker, Richard, Donovan, Katherine A., Sievers, Quinlan L., Koeppel, Jonas, Suchyta, Dakota, Sperling, Adam S., Fink, Emma C., Gasser, Jessica A., Wang, Li R., Corsello, Steven M., Sellar, Rob S., Jan, Max, Gillingham, Dennis, Scholl, Claudia, Fröhling, Stefan, Golub, Todd R., Fischer, Eric S., Thomä, Nicolas H., Ebert, Benjamin L.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486275/
https://ncbi.nlm.nih.gov/pubmed/32494016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2374-x
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