A CGRP receptor antagonist peptide formulated for nasal administration to treat migraine

OBJECTIVES: To investigate the formulation of the peptide-based antagonist ((34)Pro,(35)Phe)CGRP(27–37), of the human calcitonin gene-related peptide (CGRP) receptor as a potential nasally delivered migraine treatment. METHODS: Peptide sequences were prepared using automated methods and purified by...

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Detalhes bibliográficos
Publicado no:J Pharm Pharmacol
Main Authors: von Mentzer, Bengt, Russo, Andrew F, Zhang, Zhongming, Kuburas, Adisa, Killoran, Patrick M, D’Aloisio, Vera, Nizic, Laura, Capel, Vicky, Kendall, David A, Coxon, Christopher R, Hutcheon, Gillian A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486274/
https://ncbi.nlm.nih.gov/pubmed/32588458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jphp.13317
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