Definition of naturally processed peptides reveals convergent presentation of autoantigenic topoisomerase-I epitopes in scleroderma

OBJECTIVE: Autoimmune responses to DNA topoisomerase-I (TOP1) are found in a subset of patients with scleroderma at high risk for interstitial lung disease (ILD) and mortality. Anti-TOP1 antibodies (ATA) are associated with specific HLA-DRB1 alleles, and the frequency of HLA-DR-restricted TOP1-speci...

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Published in:Arthritis Rheumatol
Main Authors: Tiniakou, Eleni, Fava, Andrea, McMahan, Zsuzsanna H., Guhr, Tara, O’Meally, Robert N., Shah, Ami A., Wigley, Fredrick M., Cole, Robert N., Boin, Francesco, Darrah, Erika
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486267/
https://ncbi.nlm.nih.gov/pubmed/32162841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41248
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